Capzb Family
Aliases: Cap Z, F-actin capping protein beta subunit, MGC129750, MGC129749, CAPB, CAPZB, RP4-657E11.7, MGC104401, CAPZ, CAPPB
Processes & Diseases
Processes involved: protrusion
Pfam Domain Structure
From CAPZB (human)
Members of the Capzb Family
| 1: CAPZB » | Human | Mouse | Rat | Chicken | Fly | Worm |
| CMKB | CAPZB | Capzb | Capzb | CAPZB | cpb | cap-2 |
| Entrez Gene | 832 | 12345 | 298584 | 396418 | 33346 | 174673 |
| Uniprot | CAPZB_HUMAN | CAPZB_MOUSE | CAPZB_RAT | CAPZB_CHICK | CAPZB_DROME | CAPZB_CAEEL |
| OMIM | 601572 | - | - | - | - | - |
| Reagents | - | - | - | - | - | - |
| Results | 2 available | 1 available | - | - | 3 available | - |
Family Summary
CAPZB is a member of the F-actin capping protein family. This gene encodes the beta subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments.
References
- Bhattacharya N, Ghosh S, Sept D, Cooper JA. Binding of myotrophin/V-1 to actin-capping protein: implications for how capping protein binds to the filament barbed end. J. Biol. Chem. 2006; 281:31021-30 (PubMed)
- Falck S, Paavilainen VO, Wear MA, Grossmann JG, Cooper JA, Lappalainen P. Biological role and structural mechanism of twinfilin-capping protein interaction. EMBO J. 2004; 23:3010-9 (PubMed)
- Kim K, Yamashita A, Wear MA, Maéda Y, Cooper JA. Capping protein binding to actin in yeast: biochemical mechanism and physiological relevance. J. Cell Biol. 2004; 164:567-80 (PubMed)
Consortium Results & Data
Discovery» Genes encoding cytoskeleton-associated proteins enriched in migratory cells
| Gene | Description | Nearest mammalian (Human) homolog | Fold Change |
|
cpb GeneID:33346 Entrez Flybase |
Capping protein beta Proposed Function: Actin binding and capping Conserved Protein Domains: F_actin_cap_B |
CAPZB GeneID: 832 CMKB Orthologs |
1.41
|
Discovery» wt-migratory_cells vs wt-non-migratory_cells
| Symbol | Description | Median Values | Fold Change | Probe ID |
|
cpb Flybase Entrez CMCKB |
capping protein beta |
Mig: 954.7 Non-Mig: 812.2 |
1.17540 | 141707_at |
Discovery» Drosophila Morphology Genes
| Gene | Name |
Cell Count/ Normalization |
Stellate11 NumCorners |
Stellate22 Binsum6 |
Non-Spreading3 | |
|
CG17158 Entrez Gene: 33346 |
capping protein beta Aliases: capping protein; CP beta subunit; burned; Capping-protein-beta; Ancpbeta; Capping protein; Capping Protein; capping proteinbeta |
4.125 0.454 |
2.123 | 1.229 |
Actin: 1.182 Area: 1.146 Ratio: 1.031 |
|
Discovery» MTLn3 invasive data
| Gene | mRNA | Description | Expression Ratio |
|
Capzb Entrez Gene: 12345 |
mRNA: AW556389 UniGene: Mm.2945 |
Capping protein (actin filament) muscle Z-line, beta | 2.7 |
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
| IPI | Locus | Description | CB Spectra | CB peptide | PD Spectra | PD peptide | ratio |
| IPI00218782 | CAPZB | CAPPING PROTEIN (ACTIN FILAMENT) MUSCLE Z-LINE, BETA. | 28 | 13 | 44 | 16 | 1.57 |
Proteomics» Table 2. Proteins in major organelles and subcellular compartments
| IPI | Locus | Description | CB Spectra | PD Spectra | ratio | Location |
| IPI00218782 | CAPZB | CAPPING PROTEIN (ACTIN FILAMENT) MUSCLE Z-LINE, BETA. | 28 | 44 | 1.57 | cytoskeleton |
The primary classification of CMKB families is the homeomorphic family, whose members are both homologous (evolved from a common ancestor) and homeomorphic (sharing full-length sequence similarity and a common domain architecture).