CaMKII Family

Aliases: calcium/calmodulin-dependent protein kinase IIA, CaMK-II alpha subunit, CaM-kinase II alpha chain, CaM kinase II alpha subunit, calcium/calmodulin-dependent protein kinase II alpha-B subunit, calcium/calmodulin-dependent protein kinase type II alpha chain, CAMKA, CAMK2A, KIAA0968

Pfam Domain Structure

From CAMK2A (human)

Members of the CaMKII Family
1: CAMK2A » Human Mouse Rat Chicken Fly Worm
CMKB CAMK2A Camk2a Camk2a CAMK2A - -
Entrez Gene 815 12322 25400 374175 - -
Uniprot KCC2A_HUMAN KCC2A_MOUSE KCC2A_RAT - - -
OMIM 114078 - - - - -
Reagents - - - - - -
Results 2 available - - - - -
2: CAMK2B » Human Mouse Rat Chicken Fly Worm
CMKB CAMK2B Camk2b Camk2b CAMK2B - -
Entrez Gene 816 12323 24245 374174 - -
Uniprot KCC2B_HUMAN KCC2B_MOUSE KCC2B_RAT - - -
OMIM 607707 - - - - -
Reagents - - - - - -
Results 2 available - - - - -
3: CAMK2D » Human Mouse Rat Chicken Fly Worm
CMKB CAMK2D Camk2d Camk2d CAMK2D CaMKII unc-43
Entrez Gene 817 108058 24246 422688 43828 177921
Uniprot KCC2D_HUMAN KCC2D_MOUSE KCC2D_RAT KCC2D_CHICK KCC2A_DROME -
OMIM 607708 - - - - -
Reagents - - - - - -
Results 3 available - - - 2 available -
4: CAMK2G » Human Mouse Rat Chicken Fly Worm
CMKB CAMK2G Camk2g Camk2g CAMK2G - -
Entrez Gene 818 12325 171140 423737 - -
Uniprot KCC2G_HUMAN KCC2G_MOUSE KCC2G_RAT - - -
OMIM 602123 - - - - -
Reagents - - - - - -
Results 2 available 1 available - - - -
Family Summary

The Ca2+/calmodulin-dependent protein kinase, CaMK-II, belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The CamKII Family consists of four different chains: alpha, beta, gamma, and delta. CAMKII has been linked to cell migration, cell cycle control, cell polarity and cytoskeletal behaviors in non-neuronal cells.

References
  1. Colomer J, Means AR. Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease. Subcell. Biochem. 2007; 45:169-214 (PubMed)
  2. Griffith LC. Regulation of calcium/calmodulin-dependent protein kinase II activation by intramolecular and intermolecular interactions. J. Neurosci. 2004; 24:8394-8 (PubMed)
  3. Lantsman K, Tombes RM. CaMK-II oligomerization potential determined using CFP/YFP FRET. Biochim. Biophys. Acta 2005; 1746:45-54 (PubMed)
  4. Liu X, Yao M, Li N, Wang C, Zheng Y, Cao X. CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages. Blood 2008; 112:4961-70 (PubMed)
  5. Pitt GS. Calmodulin and CaMKII as molecular switches for cardiac ion channels. Cardiovasc. Res. 2007; 73:641-7 (PubMed)
  6. Seward ME, Easley CA, McLeod JJ, Myers AL, Tombes RM. Flightless-I, a gelsolin family member and transcriptional regulator, preferentially binds directly to activated cytosolic CaMK-II. FEBS Lett. 2008; 582:2489-95 (PubMed)
  7. Si J, Mueller L, Collins SJ. CaMKII regulates retinoic acid receptor transcriptional activity and the differentiation of myeloid leukemia cells. J. Clin. Invest. 2007; 117:1412-21 (Full Text)
Consortium Results & Data
Discovery» PyMT invasive data
Gene mRNA Description Expression Ratio
Camk2g
Entrez Gene: 12325
mRNA: W71216
UniGene: Mm.235182
Calcium/calmodulin-dependent protein kinase II gamma 4.35
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
CAMK2G
Aliases: CAMK, CAMKG, CAMK-II
Entrez Gene: 818
siRNA catalog
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
mRNA: NM_001222
Library: Kinase
Classification: Ser/Thr Kinase
Final bin: Discordant
SMARTpool bin: Impaired
Avg area: 2.43
Avg Alamar: 0.86
Knockdown %: 40-50
ERBB2: No Change
CAMK2G
Link
CAMK2G
Link
 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
CAMK2G
Aliases: CAMK, CAMKG, CAMK-II
Entrez Gene: 818
siRNA catalog
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
mRNA: NM_001222
Library: Kinase
CAMK2G
Link
CAMK2G
Link
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
CAMK2A
Aliases: CAMKA
Entrez Gene: 815
siRNA catalog
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
mRNA: NM_015981
Library: Kinase
Classification: Ser/Thr Kinase
Final bin: Discordant
SMARTpool bin: Impaired
Avg area: 2.40
Avg Alamar: 0.84
Knockdown %: 90-100
ERBB2: No Change
CAMK2A
Link
CAMK2A
Link
 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
CAMK2A
Aliases: CAMKA
Entrez Gene: 815
siRNA catalog
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
mRNA: NM_015981
Library: Kinase
CAMK2A
Link
CAMK2A
Link
Discovery» wt-migratory_cells vs wt-non-migratory_cells
Symbol Description Median Values Fold Change Probe ID
CaMKII
Flybase
Entrez
CMCKB
Calcium/calmodulin-dependent protein kinase II Mig: 202.4
Non-Mig: 189.7
1.06690 151686_s_at
Discovery» Drosophila Morphology Genes
Gene Name Cell Count/
Normalization
Stellate11
NumCorners
Stellate22
Binsum6
Non-Spreading3
CG18069
Entrez Gene: 43828
Calcium/calmodulin-dependent protein kinase II
Aliases: calmodulin-dependent kinase; CaM kinase II; CaM kinase; calcium/ calmodulin-dependent protein kinase II; Ca[2+]/Calmodulin-dependent protein kinase II; calmodulin-dependent protein kinase II; Calmodulin kinase II; CaM-kinase-II; Ca[2+]/calmodulin-dependent protein kinase II
14.500
1.157
1.17 1.056 Actin: 1.149
Area: 1.048
Ratio: 1.096
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
CAMK2D
Aliases: CAMKD
Entrez Gene: 817
siRNA catalog
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta
mRNA: NM_001221
Library: Kinase
Classification: Ser/Thr Kinase
Final bin: No Phenotype
SMARTpool bin: No change
Avg area: 1.77
Avg Alamar: 0.94
Knockdown %: 60-70
  CAMK2D
Link
CAMK2D
Link
 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
CAMK2D
Aliases: CAMKD
Entrez Gene: 817
siRNA catalog
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta
mRNA: NM_001221
Library: Kinase
CAMK2D
Link
CAMK2D
Link
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00172636 CAMK2D CAMK2D PROTEIN. 4 4 12 10 3.00
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
CAMK2B
Aliases: CAM2, CAMK2, CAMKB
Entrez Gene: 816
siRNA catalog
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta
mRNA: NM_001220
Library: Kinase
Classification: Ser/Thr Kinase
Final bin: Impaired - HC
SMARTpool bin: Impaired
Avg area: 2.51
Avg Alamar: 0.85
Knockdown %: 80-90
ERBB2: No Change
CAMK2B
Link
CAMK2B
Link
Impaired B
CAMK2B
Link
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
CAMK2B
Aliases: CAM2, CAMK2, CAMKB
Entrez Gene: 816
siRNA catalog
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta
mRNA: NM_001220
Library: Kinase
CAMK2B
Link
CAMK2B
Link
Consortium Related Products*
Biosensors » activity page
Ortholog Species Name Type Source Publications
CAMK2A none CaMKII Intramolecular FRET between FPs - YFP-CaMKII-CFP
-
Takao et al.

* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.

The primary classification of CMKB families is the homeomorphic family, whose members are both homologous (evolved from a common ancestor) and homeomorphic (sharing full-length sequence similarity and a common domain architecture).