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Dynactin 1 Family

Aliases: p150-glued, dynactin 1, p150, Glued homolog, 150 kDa dynein-associated polypeptide, P135, DCTN1, HMN7B, DP-150, DAP-150

Pfam Domain Structure

From DCTN1 (human)

Members of the Dynactin 1 Family
1: DCTN1 » Human Mouse Rat Chicken Fly Worm
CMKB DCTN1 Dctn1 Dctn1 DCTN1 Gl dnc-1
Entrez Gene 1639 13191 29167 426238 39536 177987
Uniprot DCTN1_HUMAN DCTN1_MOUSE DCTN1_RAT DCTN1_CHICK DCTN1_DROME -
OMIM 601143 - - - - -
Reagents - - - - - -
Results 2 available - - - 2 available -
Family Summary

Dynactin is a complex consisting of 10 subunits, involved in a diverse cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. Dynactin 1 is the largest of the subunits that make up the Dynactin complex and binds to the Dynein intermediate chain.

References
  1. Dujardin DL, Vallee RB. Dynein at the cortex. Curr. Opin. Cell Biol. 2002; 14:44-9 (PubMed)
  2. Schroer TA. Dynactin. Annu. Rev. Cell Dev. Biol. 2004; 20:759-79 (PubMed)
  3. Vallee RB, Williams JC, Varma D, Barnhart LE. Dynein: An ancient motor protein involved in multiple modes of transport. J. Neurobiol. 2004; 58:189-200 (PubMed)
  4. Welte MA. Bidirectional transport along microtubules. Curr. Biol. 2004; 14:R525-37 (PubMed)
Consortium Results & Data
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00029485 DCTN1 SPLICE ISOFORM P150 OF DYNACTIN-1. 42 20 77 33 1.83
Proteomics» Table 2. Proteins in major organelles and subcellular compartments
IPI Locus Description CB Spectra PD Spectra ratio Location
IPI00029485 DCTN1 SPLICE ISOFORM P150 OF DYNACTIN-1. 42 77 1.83 cytoskeleton
Discovery» wt-migratory_cells vs wt-non-migratory_cells
Symbol Description Median Values Fold Change Probe ID
Gl
Flybase
Entrez
CMCKB
 Glued Mig: 195.7
Non-Mig: 141.2
 1.38600 143177_at
Discovery» Drosophila Morphology Genes
Gene Name Cell Count/
Normalization 		Stellate11
NumCorners 		Stellate22
Binsum6 		Non-Spreading3
CG9206
Entrez Gene: 39536
 Glued
Aliases: dynactin; Gliotactin; Dynactin 		6.053
0.900 		0.753 0.931 Actin: 1.073
Area: 1.055
Ratio: 1.017

The primary classification of CMKB families is the homeomorphic family, whose members are both homologous (evolved from a common ancestor) and homeomorphic (sharing full-length sequence similarity and a common domain architecture).