Capping protein Family
Aliases: gelsolin-like capping protein, macrophage capping protein, actin-regulatory protein CAP-G, MCP, CAPG, AFCP
Processes & Diseases
Processes involved: protrusion
Pfam Domain Structure
From CAPG (human)
Members of the Capping protein Family
| 1: CAPG » | Human | Mouse | Rat | Chicken | Fly | Worm |
| CMKB | CAPG | Capg | Capg | - | - | - |
| Entrez Gene | 822 | 12332 | 297339 | - | - | - |
| Uniprot | CAPG_HUMAN | CAPG_MOUSE | CAPG_RAT | - | - | - |
| OMIM | 153615 | - | - | - | - | - |
| Reagents | - | - | - | - | - | - |
| Results | 2 available | 1 available | - | - | - | - |
Family Summary
Capping protein (CAPG) is a member of the gelsolin/villin family of actin-regulatory proteins. They reversibly block the barbed ends of F-actin filaments and contributes in this way to the control of actin-based motility in non-muscle cells.
References
- Hubert T, Van Impe K, Vandekerckhove J, Gettemans J. The actin-capping protein CapG localizes to microtubule-dependent organelles during the cell cycle. Biochem. Biophys. Res. Commun. 2009; 380:166-70 (PubMed)
- Mejillano MR, Kojima S, Applewhite DA, Gertler FB, Svitkina TM, Borisy GG. Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Cell 2004; 118:363-73 (PubMed)
- Silacci P, Mazzolai L, Gauci C, Stergiopulos N, Yin HL, Hayoz D. Gelsolin superfamily proteins: key regulators of cellular functions. Cell. Mol. Life Sci. 2004; 61:2614-23 (PubMed)
Consortium Results & Data
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
| IPI | Locus | Description | CB Spectra | CB peptide | PD Spectra | PD peptide | ratio |
| IPI00027341 | CAPG | MACROPHAGE CAPPING PROTEIN. | 8 | 6 | 22 | 5 | 2.75 |
Proteomics» Table 2. Proteins in major organelles and subcellular compartments
| IPI | Locus | Description | CB Spectra | PD Spectra | ratio | Location |
| IPI00027341 | CAPG | MACROPHAGE CAPPING PROTEIN. | 8 | 22 | 2.75 | nucleus |
| IPI00027341 | CAPG | MACROPHAGE CAPPING PROTEIN. | 8 | 22 | 2.75 | cytoskeleton |
Discovery» MTLn3 invasive data
| Gene | mRNA | Description | Expression Ratio |
|
Capg Entrez Gene: 12332 |
mRNA: AW541453 UniGene: Mm.18626 |
Capping protein (actin filament), gelsolin-like | 2.5 |
The primary classification of CMKB families is the homeomorphic family, whose members are both homologous (evolved from a common ancestor) and homeomorphic (sharing full-length sequence similarity and a common domain architecture).