Zyx mouse: zyxin
Aliases: zyxin, 9530098H06Rik, Zyx, R75157
Pfam Domain Structure
From Zyx (mouse) - phosphorylation sites added via direct mapping
Protein Overview
| Official Gene Name | Zyx (M. musculus) |
| RefSeq Protein Name | zyxin |
| UniProt Gene Symbol | ZYX_MOUSE |
References
- Bai CY, Ohsugi M, Abe Y, Yamamoto T. ZRP-1 controls Rho GTPase-mediated actin reorganization by localizing at cell-matrix and cell-cell adhesions. J. Cell. Sci. 2007; 120:2828-37 (PubMed)
- Brancaccio M, Hirsch E, Notte A, Selvetella G, Lembo G, Tarone G. Integrin signalling: the tug-of-war in heart hypertrophy. Cardiovasc. Res. 2006; 70:422-33 (PubMed)
- Drees BE, Andrews KM, Beckerle MC. Molecular dissection of zyxin function reveals its involvement in cell motility. J. Cell Biol. 1999; 147:1549-60 (PubMed)
- Gorenne I, Jin L, Yoshida T, Sanders JM, Sarembock IJ, Owens GK, Somlyo AP, Somlyo AV. LPP expression during in vitro smooth muscle differentiation and stent-induced vascular injury. Circ. Res. 2006; 98:378-85 (PubMed)
- Guo B, Sallis RE, Greenall A, Petit MM, Jansen E, Young L, Van de Ven WJ, Sharrocks AD. The LIM domain protein LPP is a coactivator for the ETS domain transcription factor PEA3. Mol. Cell. Biol. 2006; 26:4529-38 (PubMed)
- Hansen MD, Beckerle MC. Opposing roles of zyxin/LPP ACTA repeats and the LIM domain region in cell-cell adhesion. J. Biol. Chem. 2006; 281:16178-88 (PubMed)
- Jin L, Kern MJ, Otey CA, Wamhoff BR, Somlyo AV. Angiotensin II, focal adhesion kinase, and PRX1 enhance smooth muscle expression of lipoma preferred partner and its newly identified binding partner palladin to promote cell migration. Circ. Res. 2007; 100:817-25 (PubMed)
- Lai YJ, Chen CS, Lin WC, Lin FT. c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration. Mol. Cell. Biol. 2005; 25:5859-68 (PubMed)
- Luderer HF, Bai S, Longmore GD. The LIM protein LIMD1 influences osteoblast differentiation and function. Exp. Cell Res. 2008; 314:2884-94 (PubMed)
- Moon HS, Even-Ram S, Kleinman HK, Cha HJ. Zyxin is upregulated in the nucleus by thymosin beta4 in SiHa cells. Exp. Cell Res. 2006; 312:3425-31 (PubMed)
- Spinardi L, Marchisio PC. Podosomes as smart regulators of cellular adhesion. Eur. J. Cell Biol. 2006; 85:191-4 (PubMed)
- Yoshigi M, Hoffman LM, Jensen CC, Yost HJ, Beckerle MC. Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement. J. Cell Biol. 2005; 171:209-15 (PubMed)
- Zaidel-Bar R, Cohen M, Addadi L, Geiger B. Hierarchical assembly of cell-matrix adhesion complexes. Biochem. Soc. Trans. 2004; 32:416-20 (PubMed)
Consortium Results & Data
Results & Data
| Ortholog | Species | Type | Description | Method | Status | Source | Publications |
|---|---|---|---|---|---|---|---|
| ZYX | none | phosphorylation site | Zyxin | TAP-tagged GST-Zyxin | 4 phospho-sites in 78.0% coverage of 564 aa | Hoffman, Parsons |
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Discovery» siRNA migration screen using a wound healing approach
| Gene | Description | MCF-10A phenotype | Secondary screen | Wound Image | Morphology | Time-lapse |
|
ZYX Aliases: ESP-2, HED-2 Entrez Gene: 7791 siRNA catalog |
zyxin mRNA: NM_003461 Library: MAR Classification: cytoskeletal Focal Adhesion Related: Yes |
Final bin: Discordant SMARTpool bin: No change Avg area: 1.27 Avg Alamar: 0.89 Knockdown %: not done |
 Link |
 Link |
Discovery» siRNA Focal Adhesion Phenotypes
| Gene | Description | High-Res | Montage |
|
ZYX Aliases: ESP-2, HED-2 Entrez Gene: 7791 siRNA catalog |
zyxin mRNA: NM_003461 Library: MAR |
 Link |
 Link |
Discovery» MTLn3 invasive data
| Gene | mRNA | Description | Expression Ratio |
|
Zyx Entrez Gene: 22793 |
mRNA: AW555565 UniGene: Mm.282303 |
Zyxin | 2.9 |
Consortium Related Products*
Mice » activity page
| Ortholog | Species | Name | Method | Phenotype | Status | Jax Availability | Source | Publications |
|---|---|---|---|---|---|---|---|---|
| ZYX | mouse | Zyxin | - |
Viable, fertile, no obvious histological abnormalities in any of the organs examined. | completed |
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Hoffman et al. |
* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.
Isoforms
| Isoform Name | RefSeq Protein | RefSeq mRNA | Swissprot ID |
|---|---|---|---|
| NP_035907 | NM_011777 | Q62523 |
bold indicates the primary isoform
Pathways