ITGA1 human: integrin, alpha 1

Aliases: laminin and collagen receptor, integrin, alpha 1, very late activation protein 1, VLA1, ITGA1, CD49a

Pfam Domain Structure

From ITGA1 (human)

Protein Overview
Official Gene Name ITGA1 (H. sapiens)
RefSeq Protein Name integrin, alpha 1
UniProt Gene Symbol ITA1_HUMAN
UniProt Name Integrin alpha-1
Entrez Gene Summary This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq]
References
  1. Caswell PT, Vadrevu S, Norman JC. Integrins: masters and slaves of endocytic transport. Nat. Rev. Mol. Cell Biol. 2009; 10:843-53 (PubMed)
  2. Delon I, Brown NH. Integrins and the actin cytoskeleton. Curr. Opin. Cell Biol. 2007; 19:43-50 (PubMed)
  3. Eckes B, Zweers MC, Zhang ZG, Hallinger R, Mauch C, Aumailley M, Krieg T. Mechanical tension and integrin alpha 2 beta 1 regulate fibroblast functions. J. Investig. Dermatol. Symp. Proc. 2006; 11:66-72 (PubMed)
  4. Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance. J. Cell. Sci. 2006; 119:3901-3 (PubMed)
  5. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002; 110:673-87 (PubMed)
  6. Kim M, Carman CV, Springer TA. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 2003; 301:1720-5 (PubMed)
  7. Luo BH, Carman CV, Springer TA. Structural basis of integrin regulation and signaling. Annu. Rev. Immunol. 2007; 25:619-47 (Full Text)
  8. Luo BH, Springer TA. Integrin structures and conformational signaling. Curr. Opin. Cell Biol. 2006; 18:579-86 (Full Text)
  9. Vicente-Manzanares M, Choi CK, Horwitz AR. Integrins in cell migration--the actin connection. J. Cell. Sci. 2009; 122:199-206 (Full Text)
  10. Wiesner S, Legate KR, Fässler R. Integrin-actin interactions. Cell. Mol. Life Sci. 2005; 62:1081-99 (PubMed)
  11. Zaidel-Bar R, Geiger B. The switchable integrin adhesome. J. Cell. Sci. 2010; 123:1385-8 (Full Text)
  12. Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat. Cell Biol. 2007; 9:858-67 (Full Text)
  13. Zargham R. Tensegrin in context: Dual role of alpha8 integrin in the migration of different cell types. Cell Adh Migr 2010; 4: (Full Text)
  14. Zhu CQ, Popova SN, Brown ER, Barsyte-Lovejoy D, Navab R, Shih W, Li M, Lu M, Jurisica I, Penn LZ, Gullberg D, Tsao MS. Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2007; 104:11754-9 (Full Text)
  15. Zutter MM, Edelson BT. The alpha2beta1 integrin: a novel collectin/C1q receptor. Immunobiology 2007; 212:343-53 (PubMed)
Consortium Results & Data
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00472202 ITGA1 INTEGRIN, ALPHA 1 PRECURSOR . 0 0 5 3 PDU
IPI00106698 ITGA1 PELOTA HOMOLOG. 2 2 5 5 2.50
Proteomics» Table 2. Proteins in major organelles and subcellular compartments
IPI Locus Description CB Spectra PD Spectra ratio Location
IPI00472202 ITGA1 INTEGRIN, ALPHA 1 PRECURSOR . 0 5 PDU nucleus
Isoforms
Isoform Name RefSeq Protein RefSeq mRNA Swissprot ID
NP_852478 NM_181501 P56199

bold indicates the primary isoform

Pathways

How many degrees of interaction?

Update
Legend: Legend for CMKB pathways