Ptpn3 mouse: protein tyrosine phosphatase, non-receptor type 3

Aliases: protein tyrosine phosphatase, non-receptor type 3, protein-tyrosine phosphatase H1, Ptpn3, RP23-293N9.2, 9530011I20Rik, PTP-H1, PTPCL

Pfam Domain Structure

From Ptpn3 (mouse)

Protein Overview
Official Gene Name Ptpn3 (M. musculus)
RefSeq Protein Name protein tyrosine phosphatase, non-receptor type 3
UniProt Gene Symbol PTPN3_MOUSE
References
  1. Andersen JN, Del Vecchio RL, Kannan N, Gergel J, Neuwald AF, Tonks NK. Computational analysis of protein tyrosine phosphatases: practical guide to bioinformatics and data resources. Methods 2005; 35:90-114 (PubMed)
  2. Andersen JN, Jansen PG, Echwald SM, Mortensen OH, Fukada T, Del Vecchio R, Tonks NK, Møller NP. A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage. FASEB J. 2004; 18:8-30 (PubMed)
  3. Cho SH, Lee CH, Ahn Y, Kim H, Kim H, Ahn CY, Yang KS, Lee SR. Redox regulation of PTEN and protein tyrosine phosphatases in H(2)O(2) mediated cell signaling. FEBS Lett. 2004; 560:7-13 (PubMed)
  4. Easty D, Gallagher W, Bennett DC. Protein tyrosine phosphatases, new targets for cancer therapy. Curr Cancer Drug Targets 2006; 6:519-32 (PubMed)
  5. Freiss G, Vignon F. Protein tyrosine phosphatases and breast cancer. Crit. Rev. Oncol. Hematol. 2004; 52:9-17 (PubMed)
  6. Liang F, Kumar S, Zhang ZY. Proteomic approaches to studying protein tyrosine phosphatases. Mol Biosyst 2007; 3:308-16 (PubMed)
  7. Tiganis T, Bennett AM. Protein tyrosine phosphatase function: the substrate perspective. Biochem. J. 2007; 402:1-15 (Full Text)
  8. Tonks NK. Redox redux: revisiting PTPs and the control of cell signaling. Cell 2005; 121:667-70 (PubMed)
  9. Tonks NK. Protein tyrosine phosphatases: from genes, to function, to disease. Nat. Rev. Mol. Cell Biol. 2006; 7:833-46 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
Gene Description     MCF-10A phenotype     Secondary screen Wound Image Morphology Time-lapse
PTPN3
Aliases: PTPH1
Entrez Gene: 5774
siRNA catalog
protein tyrosine phosphatase, non-receptor type 3
mRNA: NM_002829
Library: Phosphatase
Classification: Phosphatase
Focal Adhesion Related: Yes
Final bin: Discordant
SMARTpool bin: No change
Avg area: 1.60
Avg Alamar: 0.93
Knockdown %: failed
  PTPN3
Link
PTPN3
Link
 
Discovery» siRNA Focal Adhesion Phenotypes
Gene Description High-Res Montage
PTPN3
Aliases: PTPH1
Entrez Gene: 5774
siRNA catalog
protein tyrosine phosphatase, non-receptor type 3
mRNA: NM_002829
Library: Phosphatase
PTPN3
Link
PTPN3
Link
Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
IPI Locus Description CB Spectra CB peptide PD Spectra PD peptide ratio
IPI00289649 PTPN3 TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 3. 1 1 1 1 1.00
Proteomics» Table 2. Proteins in major organelles and subcellular compartments
IPI Locus Description CB Spectra PD Spectra ratio Location
IPI00289649 PTPN3 TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 3. 1 1 1 cytoskeleton
Isoforms
Isoform Name RefSeq Protein RefSeq mRNA Swissprot ID
NP_035337 NM_011207 A2ALK8

bold indicates the primary isoform