PARVA human: parvin, alpha
Aliases: actopaxin, parvin, alpha, matrix-remodelling associated 2, alpha-parvin, FLJ10793, PARVA, MXRA2, FLJ12254
Pfam Domain Structure
From PARVA (human) - phosphorylation sites added via direct mapping
Protein Overview
| Official Gene Name | PARVA (H. sapiens) |
| RefSeq Protein Name | parvin, alpha |
| UniProt Gene Symbol | PARVA_HUMAN |
| UniProt Name | Alpha-parvin |
| Entrez Gene Summary | This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq] |
References
- Legate KR, Montañez E, Kudlacek O, Fässler R. ILK, PINCH and parvin: the tIPP of integrin signalling. Nat. Rev. Mol. Cell Biol. 2006; 7:20-31 (PubMed)
- Olski TM, Noegel AA, Korenbaum E. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily. J. Cell. Sci. 2001; 114:525-38 (PubMed)
- Sepulveda JL, Wu C. The parvins. Cell. Mol. Life Sci. 2006; 63:25-35 (PubMed)
- Wu C. The PINCH-ILK-parvin complexes: assembly, functions and regulation. Biochim. Biophys. Acta 2004; 1692:55-62 (PubMed)
Consortium Results & Data
Results & Data
| Ortholog | Species | Type | Description | Method | Status | Source | Publications |
|---|---|---|---|---|---|---|---|
| PARVA | none | phosphorylation site | Parvin | Ectopic expression in HEK cells | 4 phospho-sites in 88.7% coverage of 380 aa | Parsons |
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Discovery» siRNA migration screen using a wound healing approach
| Gene | Description | MCF-10A phenotype | Secondary screen | Wound Image | Morphology | Time-lapse |
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PARVA Aliases: MXRA2 Entrez Gene: 55742 siRNA catalog |
parvin, alpha mRNA: NM_018222 Library: MAR Classification: cytoskeletal Focal Adhesion Related: Yes |
Final bin: Accelerated - MC SMARTpool bin: Accelerated Avg area: 0.49 Avg Alamar: 1.12 Knockdown %: not done |
ERBB2: Accelerated |
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Discovery» siRNA Focal Adhesion Phenotypes
| Gene | Description | High-Res | Montage |
|
PARVA Aliases: MXRA2 Entrez Gene: 55742 siRNA catalog |
parvin, alpha mRNA: NM_018222 Library: MAR |
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Proteomics» Table 1. Identification and Quantitation of Proteins from Cell Body (CB) and Pseudopodium (PD) fractions
| IPI | Locus | Description | CB Spectra | CB peptide | PD Spectra | PD peptide | ratio |
| IPI00018963 | PARVA | SPLICE ISOFORM 1 OF ALPHA-PARVIN. | 3 | 2 | 12 | 5 | 4.00 |
Proteomics» Table 2. Proteins in major organelles and subcellular compartments
| IPI | Locus | Description | CB Spectra | PD Spectra | ratio | Location |
| IPI00018963 | PARVA | SPLICE ISOFORM 1 OF ALPHA-PARVIN. | 3 | 12 | 4 | nucleus |
| IPI00018963 | PARVA | SPLICE ISOFORM 1 OF ALPHA-PARVIN. | 3 | 12 | 4 | cytoskeleton |
Proteomics» Table 3. Quantitation of phosphopeptides identified in Pseudopodium (PD) and Cell Body (CB) fractions
| IPI | Locus | Description | peptide | pdcb_p | pdcb_t | ratio | Mouse homology | Rat homology | Zebrafish homology | sd | Variable sites |
| IPI00018963 | PARVA | ALPHA-PARVIN. | SPTPKS*PPSR | 1.7 | 4.00 | 0.43 | +++ | +++ | ++ | 0.02 | |
| IPI00018963 | PARVA | ALPHA-PARVIN. | SPSVPKS*PTPKS*PPSR | 2 | 4.00 | 0.5 | ++ | +++ | ++ | 0.22 |
Consortium Related Products*
Mice » activity page
| Ortholog | Species | Name | Method | Phenotype | Status | Jax Availability | Source | Publications |
|---|---|---|---|---|---|---|---|---|
| PARVA | mouse | CH-ILKBP - siRNA in HeLa cells | - |
40% of cells underwent apoptosis 48 hours after siRNA transfection. Loss of membrane translocation of PKB/Akt. | completed |
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Fukuda et al. |
* The resources presented here are largely those generated by the Consortium. The sidebar provides public databases that complement Consortium activities. For mice and biosensors, a public database is not available and therefore we have attempted to generate a migration related list for your convenience.
Isoforms
| Isoform Name | RefSeq Protein | RefSeq mRNA | Swissprot ID |
|---|---|---|---|
| NP_060692 | NM_018222 | Q9NVD7-1 |
bold indicates the primary isoform
Pathways