ACVR1 human: activin A receptor, type I
Aliases: activin A type I receptor, TGF-B superfamily receptor type I, serine/threonine-protein kinase receptor R1, hydroxyalkyl-protein kinase, activin A receptor, type II-like kinase 2, TSRI, ACVR1A, FOP, ALK2, ACVR1, SKR1, ACTRI, ACVRLK2
Pfam Domain Structure
From ACVR1 (human)
Protein Overview
| Official Gene Name | ACVR1 (H. sapiens) |
| RefSeq Protein Name | activin A receptor, type I |
| UniProt Gene Symbol | ACVR1_HUMAN |
| UniProt Name | Activin receptor type-1 |
| Enzyme Commission | 2.7.11.30 |
| Entrez Gene Summary | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq] |
References
- Chen YG, Wang Q, Lin SL, Chang CD, Chuang J, Chung J, Ying SY. Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis. Exp. Biol. Med. (Maywood) 2006; 231:534-44 (PubMed)
- Harrison CA, Wiater E, Gray PC, Greenwald J, Choe S, Vale W. Modulation of activin and BMP signaling. Mol. Cell. Endocrinol. 2004; 225:19-24 (PubMed)
- Kaplan FS, Groppe J, Pignolo RJ, Shore EM. Morphogen receptor genes and metamorphogenes: skeleton keys to metamorphosis. Ann. N. Y. Acad. Sci. 2007; 1116:113-33 (PubMed)
- Tsuchida K, Nakatani M, Yamakawa N, Hashimoto O, Hasegawa Y, Sugino H. Activin isoforms signal through type I receptor serine/threonine kinase ALK7. Mol. Cell. Endocrinol. 2004; 220:59-65 (PubMed)
- Waite KA, Eng C. BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels. Hum. Mol. Genet. 2003; 12:679-84 (PubMed)
Consortium Results & Data
Discovery» siRNA migration screen using a wound healing approach
| Gene | Description | MCF-10A phenotype | Secondary screen | Wound Image | Morphology | Time-lapse |
|
ACVR1 Aliases: FOP, ALK2, SKR1, ACTRI, ACVRLK2 Entrez Gene: 90 siRNA catalog |
activin A receptor, type I mRNA: NM_001105 Library: Kinase Classification: Ser/Thr Kinase |
Final bin: Accelerated - HC SMARTpool bin: Accelerated Avg area: 0.18 Avg Alamar: 1.03 Knockdown %: 80-90 |
ERBB2: Accelerated |
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Accelerated unique Link |
Discovery» siRNA Focal Adhesion Phenotypes
| Gene | Description | High-Res | Montage |
|
ACVR1 Aliases: FOP, ALK2, SKR1, ACTRI, ACVRLK2 Entrez Gene: 90 siRNA catalog |
activin A receptor, type I mRNA: NM_001105 Library: Kinase |
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Discovery» wt-migratory_cells vs wt-non-migratory_cells
| Symbol | Description | Median Values | Fold Change | Probe ID |
|
sax Flybase Entrez CMCKB |
saxophone |
Mig: 147.0 Non-Mig: 104.4 |
1.40800 | 152507_at |
Isoforms
| Isoform Name | RefSeq Protein | RefSeq mRNA | Swissprot ID |
|---|---|---|---|
| isoform 1 | NP_001096 | NM_001105 | Q04771 |
| NP_001104537 | NM_001111067 | Q04771 |
bold indicates the primary isoform