ITGB1BP1 human: integrin beta 1 binding protein 1
Aliases: bodenin, integrin cytoplasmic domain-associated protein 1, integrin cytoplasmic domain-associated protein 1-beta, integrin cytoplasmic domain-associated protein 1-alpha, ICAP1, ITGB1BP1, DKFZp686K08158, ICAP-1alpha, ICAP1A, ICAP1B, ICAP-1A, ICAP-1B
Pfam Domain Structure
From ITGB1BP1 (human)
Protein Overview
| Official Gene Name | ITGB1BP1 (H. sapiens) |
| RefSeq Protein Name | integrin beta 1 binding protein 1 |
| UniProt Gene Symbol | ITBP1_HUMAN |
| UniProt Name | Integrin beta-1-binding protein 1 |
| Entrez Gene Summary | The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. [provided by RefSeq] |
References
- Alvarez B, Stroeken PJ, Edel MJ, Roos E. Integrin Cytoplasmic domain-Associated Protein-1 (ICAP-1) promotes migration of myoblasts and affects focal adhesions. J. Cell. Physiol. 2008; 214:474-82 (PubMed)
- Bouvard D, Millon-Fremillon A, Dupe-Manet S, Block MR, Albiges-Rizo C. Unraveling ICAP-1 function: toward a new direction?. Eur. J. Cell Biol. 2006; 85:275-82 (PubMed)
- Stroeken PJ, Alvarez B, Van Rheenen J, Wijnands YM, Geerts D, Jalink K, Roos E. Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane. J. Cell. Physiol. 2006; 208:620-8 (PubMed)
Consortium Results & Data
Results & Data
| Ortholog | Species | Type | Description | Method | Status | Source | Publications |
|---|---|---|---|---|---|---|---|
| ITGB1BP1 | human | phosphorylation site | ICAP1 | 7 sites in 99.5% coverage of 194 amino acids | Ginsberg |
-
|
Discovery» siRNA migration screen using a wound healing approach
| Gene | Description | MCF-10A phenotype | Secondary screen | Wound Image | Morphology | Time-lapse |
|
ITGB1BP1 Aliases: ICAP1, ICAP1A, ICAP1B, ICAP-1A, ICAP-1B, ICAP-1alpha Entrez Gene: 9270 siRNA catalog |
integrin beta 1 binding protein 1 mRNA: NM_004763 Library: MAR Classification: integrin |
Final bin: Discordant SMARTpool bin: Accelerated * Avg area: 0.78 Avg Alamar: 0.91 Knockdown %: not done |
ERBB2: Accelerated |
 Link |
 Link |
Discovery» siRNA Focal Adhesion Phenotypes
| Gene | Description | High-Res | Montage |
|
ITGB1BP1 Aliases: ICAP1, ICAP1A, ICAP1B, ICAP-1A, ICAP-1B, ICAP-1alpha Entrez Gene: 9270 siRNA catalog |
integrin beta 1 binding protein 1 mRNA: NM_004763 Library: MAR |
 Link |
 Link |